Fibroblast-like synoviocytes mediate the generation of soluble PD-1 in an MMP-9-dependent manner: a novel target therapy for rheumatoid arthritis
These results indicate that plasma sPD-1 levels are positively associated with RA disease activity, supporting its potential as a complementary biomarker for monitoring disease activity (especially in combination with traditional indicators like CRP/ESR), though its standalone diagnostic value requires further validation. Furthermore, targeting sPD-1, such as with PD-L1-MSA, represents a promising complementary therapeutic candidate for alleviating RA pathology.
Authors
- Yan Shen (ORCID: https://orcid.org/0000-0001-7058-8602)
- Lulu Luo
- Yi Wang (ORCID: https://orcid.org/0000-0002-6303-385X)
- Jun Wang (ORCID: https://orcid.org/0000-0001-9957-9208)
- Yuting Zhang (ORCID: https://orcid.org/0000-0003-4204-9091)
- Ya Zhao
- Chao Yang (ORCID: https://orcid.org/0000-0003-3397-7275)
- Miao Ma (ORCID: https://orcid.org/0000-0002-9612-7940)
- Kangjie Yu
- Xiaoke Wang (ORCID: https://orcid.org/0000-0002-2421-3970)
Institutions
- Northwest University (CN)
- Xi'an Medical University (CN)
- Air Force General Hospital PLA (CN)
- Tang Du Hospital (CN)
- Xijing Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-10
- DOI
- https://doi.org/10.3389/fimmu.2025.1665078
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00