89Zr-anti-CD8 immunoPET visualizes heterogeneous intratumoral CD8+ immune responses to treatment with radiation and anti-CTLA4
Anti-CD8 immunoPET facilitates non-invasive, whole-body visualization of immune responses, and syngeneic preclinical models are a crucial tool for studying tumor infiltration of T cells in response to cancer therapies. This study characterized longitudinal CD8<sup>+</sup> T cell responses in an orthotopic mouse model of breast cancer treated with radiation and anti-CTLA4 by immunohistochemistry and anti-CD8 immunoPET, confirming an early but heterogeneous response induced by combination treatment that is detectable by imaging.
Authors
- Elizabeth Germino (ORCID: https://orcid.org/0000-0003-1396-3722)
- Kirstin A. Zettlitz (ORCID: https://orcid.org/0000-0003-4870-6603)
- Tyler Watkins
- Anna M. Wu (ORCID: https://orcid.org/0000-0001-8487-823X)
- Deirdre La Placa
- Terence M. Williams (ORCID: https://orcid.org/0000-0002-1020-0845)
- Bao Ying Chen (ORCID: https://orcid.org/0000-0001-6057-635X)
- Heather M. McGee (ORCID: https://orcid.org/0000-0003-3761-5087)
- Jennifer Chean
- Felix B. Salazar (ORCID: https://orcid.org/0009-0004-9361-1528)
- Shichang Li (ORCID: https://orcid.org/0000-0002-2583-0639)
Institutions
- City Of Hope National Medical Center (US)
- City of Hope (US)
- Theranostics (New Zealand) (NZ)
Publication Details
- Journal
- npj Imaging
- Published
- 2025-12-10
- DOI
- https://doi.org/10.1038/s44303-025-00128-5
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Radiological Society of North America