Health-related quality of life and psychosocial outcomes in long-term survivors treated with immune checkpoint inhibitors: a nationwide multicenter study
This study represents one of the largest cohorts to date evaluating survivorship issues among LTS treated with ICIs. Among patients receiving ICIs for at least six months, nearly one-third experienced impaired QoL, primarily driven by psychological distress and FoP. Further research is needed to address survivorship care in this population.
Authors
- Bahadır Köylü (ORCID: https://orcid.org/0000-0002-4462-6393)
- Tuba Ugur Tuzcu (ORCID: https://orcid.org/0000-0002-7750-814X)
- Tülay Eren (ORCID: https://orcid.org/0000-0002-0088-1149)
- Safa Can Efil (ORCID: https://orcid.org/0000-0001-9586-2858)
- S. Dogan
- Taha Koray Şahin (ORCID: https://orcid.org/0000-0002-3590-0426)
- Mevlüde İnanç (ORCID: https://orcid.org/0000-0002-3737-3420)
- Saadettin Kılıçkap (ORCID: https://orcid.org/0000-0003-1637-7390)
- Muslih Ürün (ORCID: https://orcid.org/0000-0002-9883-3398)
- Ömer Dızdar (ORCID: https://orcid.org/0000-0003-0911-9078)
- Osman Sütçüoğlu (ORCID: https://orcid.org/0000-0003-3835-2741)
- Mustafa Erman (ORCID: https://orcid.org/0000-0001-5884-4669)
- Mehmet Alı Nahıt Şendur (ORCID: https://orcid.org/0000-0001-7021-6139)
- Sercan Aksoy (ORCID: https://orcid.org/0000-0003-4984-1049)
- Arzu Yaşar (ORCID: https://orcid.org/0000-0002-0545-1383)
- Erdem Göker (ORCID: https://orcid.org/0000-0001-6180-713X)
- Mehmet Artaç (ORCID: https://orcid.org/0000-0003-2335-3354)
- Öztürk Ateş (ORCID: https://orcid.org/0000-0003-0182-3933)
- Fatih Selçukbırıcık (ORCID: https://orcid.org/0000-0002-1273-1674)
- Fatih Atalah (ORCID: https://orcid.org/0000-0002-5664-7853)
- Fadime Sinem Ardic (ORCID: https://orcid.org/0000-0002-0232-9630)
- Ahmet Fatih Oruç (ORCID: https://orcid.org/0009-0003-0923-5148)
- Atila Yıldırım (ORCID: https://orcid.org/0000-0002-6067-5646)
- Sebahattin Çelik (ORCID: https://orcid.org/0000-0003-0300-0113)
- Halil Göksel Güzel (ORCID: https://orcid.org/0000-0001-8310-1752)
- Kadriye Erkan Turan (ORCID: https://orcid.org/0000-0001-7644-6648)
- İsmail Oğuz Kara (ORCID: https://orcid.org/0000-0003-4963-2028)
- Ayla Gökmen (ORCID: https://orcid.org/0000-0002-0687-1726)
- Sedat Biter (ORCID: https://orcid.org/0000-0002-1053-0668)
- Salih Tünbekici (ORCID: https://orcid.org/0000-0001-8804-7636)
- Fatma Alev Türker
- Deniz Can Güven (ORCID: https://orcid.org/0000-0002-6924-9467)
- Banu Öztürk (ORCID: https://orcid.org/0000-0003-0290-8787)
- Özlem Çınar Özdemir (ORCID: https://orcid.org/0000-0002-9205-5652)
- İlknur Deliktaş Onur (ORCID: https://orcid.org/0000-0001-9884-5789)
- Görkem Turhan (ORCID: https://orcid.org/0000-0002-0572-4927)
- Ahmet Kürsad Disli
- Aydın Acarbay (ORCID: https://orcid.org/0000-0002-9446-9293)
- Cevat İlteriş Kıkılı (ORCID: https://orcid.org/0000-0001-8604-9988)
- Akgün Karakök (ORCID: https://orcid.org/0009-0001-9876-3932)
- Gamze Emin (ORCID: https://orcid.org/0000-0002-1549-7326)
Institutions
- Van Yüzüncü Yıl Üniversitesi (TR)
- Izmir University (TR)
- Koç University (TR)
- Ankara University (TR)
- Karadeniz Technical University (TR)
- University of Health Science (KH)
- Turkish Armed Forces (TR)
- Ege University (TR)
- Memorial Ankara Hospital (TR)
- Necmettin Erbakan University (TR)
- Ankara Onkoloji Eğitim ve Araştırma Hastanesi (TR)
- Antalya Eğitim ve Araştırma Hastanesi (TR)
- Hacettepe University Hospital (TR)
- Istinye University (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- Cukurova University (TR)
- Istanbul Medeniyet University (TR)
- Hacettepe University (TR)
- Erciyes University (TR)
- Gazi University (TR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-10
- DOI
- https://doi.org/10.3389/fimmu.2025.1693295
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Society for Medical Oncology