Effect of Esketamine on Perioperative Inflammatory Factors and Postoperative Analgesic Outcomes in Patients with Obstructive Sleep Apnea Syndrome: A Randomized Controlled Trial
Intraoperative infusion of 0.25 mg·kg<sup>-</sup> esketamine provided transient suppression of inflammatory responses and reduced early postoperative pain in OSAS patients. However, these benefits were exploratory and time-limited, and must be weighed against prolonged extubation and PACU stay.
Authors
- Jingjing Yuan (ORCID: https://orcid.org/0000-0002-3144-6123)
- Zhongyu Wang (ORCID: https://orcid.org/0000-0001-5103-6466)
- Yanle Xie
- Jianjun Yang (ORCID: https://orcid.org/0000-0001-6785-9627)
- Fei Xing (ORCID: https://orcid.org/0000-0002-8468-634X)
- Heng Wang (ORCID: https://orcid.org/0000-0002-6829-7205)
- Zenghui Liang
- Shuhan Chen
- Jing Liu (ORCID: https://orcid.org/0000-0002-5276-9669)
Institutions
- Henan University of Technology (CN)
- Henan Provincial Chest Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/dddt.s562398
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Zhengzhou University