Alterations in the composition of meibomian gland secretions in patients with meibomian gland dysfunction based on Raman spectroscopy
Compared with healthy meibum, MGD meibum exhibits reduced unsaturated lipid content, altered lipid-protein balance, and increased biochemical heterogeneity, accompanied by subtle conformational lipid changes. These findings indicate that both lipid composition and microstructural organization are disrupted in MGD. This study supports the potential of Raman spectroscopy serve as a valuable tool for analyzing meibum composition and detecting pathological changes in MGD.
Authors
- Shangkun Ou (ORCID: https://orcid.org/0000-0002-9226-5887)
- Xueer Zheng (ORCID: https://orcid.org/0000-0001-5141-9141)
- Nan Jiang (ORCID: https://orcid.org/0000-0003-2416-1653)
- Liying Zhang (ORCID: https://orcid.org/0000-0003-4517-0751)
- Lingli Zhang (ORCID: https://orcid.org/0000-0003-3832-4046)
- Yiming Wu (ORCID: https://orcid.org/0000-0002-2885-9496)
- Dan Yang (ORCID: https://orcid.org/0000-0001-5959-1202)
- Ting Mao (ORCID: https://orcid.org/0000-0002-5710-0534)
- Hao Gu
Institutions
- Guiyang Medical University (CN)
- Xiamen University (CN)
- Qingzhou City People's Hospital (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- University of Birmingham (GB)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-12-10
- DOI
- https://doi.org/10.3389/fmed.2025.1717118
- Citations
- 2
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- National Natural Science Foundation of China
- China Scholarship Council
- Xiamen University
- Guizhou Medical University