The CLIC technology for an electron flash therapy facility

Abstract The “FLASH”effect has emerged as a subject of significant interest in the field of radiation oncology due to its potential to improve the therapeutic index of radiotherapy. Over the past three decades, CERN has been advancing accelerator technology centered on X-band radiofrequency (RF) systems. This technology was originally developed to achieve the high accelerating gradients required for the Compact Linear Collider (CLIC), a proposed next-generation high-energy physics accelerator succeeding the Large Hadron Collider (LHC). Leveraging this technological foundation, the development of a compact accelerator for radiotherapy applications based on X-band technology presents an interesting opportunity. Such a system could provide both high electron energies and a reduced footprint, facilitating the investigation of Very High Energy Electron (VHEE) beams for inducing the FLASH effect in deep-seated tumors.

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Publication Details

Journal
The European Physical Journal Special Topics
Published
2025-12-10
DOI
https://doi.org/10.1140/epjs/s11734-025-02091-z
Citations
1
Primary Topic
Radiation Therapy and Dosimetry
Type
article
Field-Weighted Citation Impact
1.52
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article

The CLIC technology for an electron flash therapy facility

E. Granados, A. Grudiev, J. Bauche, J. M. Cravero et al.
1 citations
The European Physical Journal Special Topics
Radiation Therapy and Dosimetry
1.52
article

The CLIC technology for an electron flash therapy facility

E. Granados, A. Grudiev, J. Bauche, J. M. Cravero, A. Latina, Robert M. Key, Alexander Malyzhenkov, S. Doebert, O. Brunner, M. E. Angoletta, Igor Syratchev, Walter Wuensch, Rachel Corsini, V. Korchevnyuk, Ping Wang, C. Rossi, B. Frisch
article en
1 citations

Abstract

Abstract The “FLASH”effect has emerged as a subject of significant interest in the field of radiation oncology due to its potential to improve the therapeutic index of radiotherapy. Over the past three decades, CERN has been advancing accelerator technology centered on X-band radiofrequency (RF) systems. This technology was originally developed to achieve the high accelerating gradients required for the Compact Linear Collider (CLIC), a proposed next-generation high-energy physics accelerator succeeding the Large Hadron Collider (LHC). Leveraging this technological foundation, the development of a compact accelerator for radiotherapy applications based on X-band technology presents an interesting opportunity. Such a system could provide both high electron energies and a reduced footprint, facilitating the investigation of Very High Energy Electron (VHEE) beams for inducing the FLASH effect in deep-seated tumors.

The European Physical Journal Special Topics
European Organization for Nuclear Research (CH)
Openalex Percentile: Top 12%
Radiation Therapy and Dosimetry
1.52
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