Prognostic Significance of baseline systemic inflammation markers in PD-L1-negative advanced non-small cell lung cancer patients treated with the BRICS sequential regimen
Baseline CLR and LDH are independent prognostic biomarkers for PD-L1-negative NSCLC patients receiving BRICS, reflecting systemic inflammation that may limit efficacy. These markers could optimize patient stratification and guide personalized therapy.
Authors
- Yonghai Peng
- Zongyang Yu
- Ming Yin Lin (ORCID: https://orcid.org/0000-0003-2416-7326)
- Jian Wang (ORCID: https://orcid.org/0000-0002-9482-5227)
- Jian‐Xin Chen (ORCID: https://orcid.org/0000-0002-8703-5294)
- Junhui Wang (ORCID: https://orcid.org/0000-0002-6333-0096)
Institutions
- Fujian Medical University (CN)
- Quzhou City People's Hospital (CN)
- Quzhou University (CN)
- First Hospital of Jiaxing (CN)
- Pingjin Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-10
- DOI
- https://doi.org/10.3389/fimmu.2025.1686521
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00