Skewed pulmonary innate immune cell composition underlies the delayed influenza clearance in aged mice
Our findings reveal skewed acute immune responses to influenza in aged mice, which may partially account for their mild weight loss despite delayed viral clearance and highlight age-related impairments in early antiviral immunity.
Authors
- Fang Zhao (ORCID: https://orcid.org/0000-0002-5485-5333)
- Yanmin Wan (ORCID: https://orcid.org/0000-0001-5027-9423)
- Jing Wu (ORCID: https://orcid.org/0000-0002-1224-0912)
- Xiaoyang Cheng
- Zhaoqin Zhu (ORCID: https://orcid.org/0000-0003-1101-5999)
- Jialin Jin
Institutions
- Fudan University (CN)
- Shanghai Public Health Clinical Center (CN)
- Shanghai Xuhui Central Hospital (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-12-10
- DOI
- https://doi.org/10.3389/fmicb.2025.1734163
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shanghai
- National Key Research and Development Program of China