A phage displaying an Aβ-interacting peptide mitigates neurotoxicity and prevents Aβ-driven gene expression changes
These findings highlight the therapeutic potential of phage-displayed peptides in counteracting Aβ toxicity and restoring cellular homeostasis, laying a foundation for future investigations into phage-based interventions for AD.
Authors
- Alessandra Saitta
- Sabrina Conoci (ORCID: https://orcid.org/0000-0002-5874-7284)
- Luigi Chiricosta (ORCID: https://orcid.org/0000-0003-0358-7348)
- Salvatore Oddo (ORCID: https://orcid.org/0000-0001-7304-7430)
- Simone D’Angiolini (ORCID: https://orcid.org/0000-0002-1287-6400)
- Laura Maria De Plano (ORCID: https://orcid.org/0000-0003-1152-948X)
- Antonella Caccamo (ORCID: https://orcid.org/0000-0003-2615-1133)
- Alessandra Trainito (ORCID: https://orcid.org/0000-0003-1734-0354)
- Serena Silvestro (ORCID: https://orcid.org/0000-0003-3846-0785)
Institutions
- University of Messina (IT)
- Centro Neurolesi Bonino Pulejo (IT)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2025-12-10
- DOI
- https://doi.org/10.3389/fnmol.2025.1716626
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute