1,3‐Enynes in Transition Metal Catalysis: Allene Synthesis, Functionalization, and Annulation

The high reactivity and immediate accessibility of 1,3-enynes render them versatile foundational units in the synthesis of highly valuable molecular structures, encompassing propargylic, allene, and diene compounds, in addition to carbo- and heterocyclic compounds. Transition-metal catalyzed 1,4-difunctionalization of 1,3-enynes represents one of the most powerful approaches that has attracted the attention of chemists. In this review, the functionalization and annulation reactions of 1,3-enynes under various transition metal-catalyzed systems are highlighted.