Naringin as a non-antibiotic agent for multi-species oral biofilm control: in vitro antimicrobial mechanisms and in vivo safety in a rat caries model
Naringin, a natural non-antibiotic agent, effectively inhibits the "adhesion-biofilm-acid-EPS" cascade of multi-species cariogenic biofilms. Its selective efficacy against pathogens and favorable <i>in vivo</i> safety profile position it as a promising ecological agent for caries prevention by addressing oral dysbiosis at its root.
Authors
- Zeyu Wu (ORCID: https://orcid.org/0000-0002-4634-0663)
- Jin Zhao (ORCID: https://orcid.org/0000-0002-5207-4680)
- Mingqi Liu (ORCID: https://orcid.org/0000-0002-3578-9158)
- Ying Zhao (ORCID: https://orcid.org/0000-0002-3215-9986)
- Jie Song (ORCID: https://orcid.org/0009-0007-0282-9962)
- Yizinigaer Yasen
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- Xinjiang Uygur Autonomous Region Disease Prevention and Control Center (CN)
- Xinjiang Uygur Autonomous Region Institute of Metrology and Measurement (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-12-10
- DOI
- https://doi.org/10.3389/fmicb.2025.1722083
- Citations
- 1
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Xinjiang Medical University