Isoliensinine confers neuroprotection and alleviates LPS-induced neuroinflammation in microglia by regulating the MAPK/NF-κB signaling
Our findings indicate that ISO mitigates neuroinflammation by inhibiting MAPK/NF-κB signaling and provides neuroprotection by diminishing oxidative stress and mitochondrial impairment. These effects collectively enhance its neuroprotective capacity, indicating that ISO may represent a potential candidate for further investigation in AD.
Authors
- Lichen Gao (ORCID: https://orcid.org/0000-0002-6182-691X)
- Jinyue Hu
- Wei Long
- Jinda Hu
- Mengqin Yuan (ORCID: https://orcid.org/0000-0002-3957-0727)
- Sirui Wang (ORCID: https://orcid.org/0000-0001-7698-5211)
- Xinyue Tan
Institutions
- Hunan University of Science and Technology (CN)
- Central South University (CN)
- Changsha Medical University (CN)
- University of South China (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-10
- DOI
- https://doi.org/10.3389/fphar.2025.1675865
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province