Potential lipid-lowering effects of preussin B on inhibition of intestinal cholesterol absorption: integrative mechanisms of action and proteomic analysis
These findings suggest that synthetic compound 4 (preussin B) is a promising candidate for inhibiting cholesterol absorption in the treatment of hyperlipidemia.
Authors
- Wararat Chiangjong (ORCID: https://orcid.org/0000-0002-2984-3330)
- Davide Crucitti (ORCID: https://orcid.org/0009-0006-9458-9793)
- Kwanruthai Tadpetch (ORCID: https://orcid.org/0000-0002-1110-8119)
- Thaweesak Chieochansin (ORCID: https://orcid.org/0000-0003-2205-6905)
- Jakkapong Inchai (ORCID: https://orcid.org/0000-0002-9725-9611)
- Treenut Saithong (ORCID: https://orcid.org/0000-0003-2888-6854)
- Worarat Rojanaverawong (ORCID: https://orcid.org/0000-0002-4726-5490)
- Vatcharin Rukachaisirikul (ORCID: https://orcid.org/0000-0003-1517-1526)
- Adrián Mosquera Orgueira (ORCID: https://orcid.org/0000-0003-4838-6750)
- Kittisak Thongpat
- Pannita Holasut (ORCID: https://orcid.org/0009-0002-2927-0429)
- Atcharaporn Ontawong
- Chutima S. Vaddhanaphuti
- Kornwalai Tunkaew
- Hongsiree Wiriyawaree
Institutions
- Prince of Songkla University (TH)
- Mahidol University (TH)
- University of Phayao (TH)
- Ramathibodi Hospital (TH)
- Instituto de Investigación Sanitaria de Santiago (ES)
- Chiang Mai University (TH)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-10
- DOI
- https://doi.org/10.3389/fphar.2025.1708213
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Prince of Songkla University
- National Research Council of Thailand
- Royal Golden Jubilee (RGJ) Ph.D. Programme
- Center of Excellence for Innovation in Chemistry