Ribosomal protein RPL7A modulates lung adenocarcinoma progression via circRANBP17–UPF1-mediated SIRT6 degradation
Our findings demonstrate that RPL7A promotes LUAD progression through circRANBP17-UPF1-mediated SIRT6 degradation, positioning RPL7A as a potential therapeutic target in LUAD.
Authors
- Yan Pan (ORCID: https://orcid.org/0000-0003-3164-5939)
- Yang Liu (ORCID: https://orcid.org/0000-0003-4313-0932)
- Qiming Wang (ORCID: https://orcid.org/0000-0003-3217-1077)
- Zhe Zhang (ORCID: https://orcid.org/0000-0001-8695-3803)
- Yan Liu (ORCID: https://orcid.org/0000-0003-2649-2552)
- Jing Han (ORCID: https://orcid.org/0000-0003-2584-443X)
- Si Zhou
- Zhenqiang Sun (ORCID: https://orcid.org/0000-0001-5926-2716)
- Yichen Zhu (ORCID: https://orcid.org/0009-0008-9188-066X)
- Haiyang Chen
Institutions
- Zhengzhou University (CN)
- Henan Cancer Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-12-10
- DOI
- https://doi.org/10.1186/s11658-025-00779-7
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00