Association of the microbiome with pre-epithelial barrier impairment in individuals with laryngopharyngeal reflux
Our findings demonstrate that LPR is associated with both distinct salivary microbial profiles and disruption of the pre-epithelial mucosal barrier constituents. These observations support a potential role for salivary microbiota dysbiosis in the pathogenesis of LPR, highlighting a novel interconnection between microbial community perturbations and mucosal barrier dysfunction in this disease. LEVEL OF EVIDENCE：: 4 TRIAL REGISTRATION: No. ChiCTR2400091947. Registered on November 6,2024 retrospectively.
Authors
- Xingwang Jiang (ORCID: https://orcid.org/0000-0002-7594-356X)
- Xinxin Bi
- Xiaohuan Cui
- Linxi Zhou (ORCID: https://orcid.org/0000-0003-3935-0633)
- Lina Li (ORCID: https://orcid.org/0000-0001-6085-7733)
- Yanping Zhang (ORCID: https://orcid.org/0009-0008-3171-6614)
- Shuang Guo (ORCID: https://orcid.org/0009-0001-6465-6119)
- Xiao-Jie Jing
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Hebei North University (CN)
- Chinese PLA General Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Ministry of Education (SA)
- Beijing Center for Disease Prevention and Control (CN)
- Beijing Information Science & Technology University (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-12-10
- DOI
- https://doi.org/10.1186/s12866-025-04574-4
- Primary Topic
- Gastroesophageal reflux and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00