Clinical Significance of Mean and Day-to-Day Variability of Home Blood Pressure in Chronic Kidney Disease: A Retrospective Cohort Study

Mean home SBP was significantly associated with CKD progression. Although BPV alone was not independently related to outcomes, its interaction with mean SBP suggests that BP instability may exacerbate hypertension-related kidney damage. These findings highlight the clinical importance of both lowering and stabilizing BP in CKD management.