An uncertainty-driven gated feature selection network (UGFS-Net) for TG level prediction: linking high-altitude exposure to lipid metabolism disorder via elevated TG

This study developed UGFS-Net, an interpretable deep learning model that accurately predicts triglyceride levels in high-altitude migrants (R² = 0.8776) and provides well-calibrated uncertainty estimates, with identified key biomarkers offering clinical insights.

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Publication Details

Journal
Lipids in Health and Disease
Published
2025-12-10
DOI
https://doi.org/10.1186/s12944-025-02826-w
Primary Topic
High Altitude and Hypoxia
Type
article
Field-Weighted Citation Impact
0.00
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article

An uncertainty-driven gated feature selection network (UGFS-Net) for TG level prediction: linking high-altitude exposure to lipid metabolism disorder via elevated TG

Lei Zhou, Dezhi Sun, Yue Sun, Ningning Wang et al.
Lipids in Health and Disease
High Altitude and Hypoxia
article

An uncertainty-driven gated feature selection network (UGFS-Net) for TG level prediction: linking high-altitude exposure to lipid metabolism disorder via elevated TG

Lei Zhou, Dezhi Sun, Yue Sun, Ningning Wang, Wei Zhou, Nan Yan, Ziwen Zhou, Caigui Huang, Guoying Li, Yue Gao
article en

Abstract

This study developed UGFS-Net, an interpretable deep learning model that accurately predicts triglyceride levels in high-altitude migrants (R² = 0.8776) and provides well-calibrated uncertainty estimates, with identified key biomarkers offering clinical insights.

Lipids in Health and DiseaseVol. 25(1)
Qinghai University (CN), Tianjin University of Traditional Chinese Medicine (CN), University of Shanghai for Science and Technology (CN), Henan University of Traditional Chinese Medicine (CN), Chinese PLA General Hospital (CN), Chinese Institute for Brain Research (CN), Beijing Radiation Center (CN)
Openalex Percentile: Top 59%
High Altitude and Hypoxia
DOIOpen Access PDFOpenAlex
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An uncertainty-driven gated feature selection network (UGFS-Net) for TG level prediction: linking high-altitude exposure to lipid metabolism disorder via elevated TG — Lei Zhou, Dezhi Sun, et al. · Lipids in Health and Disease (2025) | TGRS Research Map | TGRS