Effect of Anti-Inflammatory Treatment on Depressive Symptom Severity and Anhedonia in Depressed Individuals With Elevated Inflammation: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Anti-inflammatory treatments may be safe and effective at reducing depressive symptoms and anhedonia in depressed individuals with heightened inflammation. Not accounting for inflammatory status may help explain prior mixed findings.
Authors
- Melis Lydston (ORCID: https://orcid.org/0000-0002-7894-4736)
- Naoise Mac Giollabhui (ORCID: https://orcid.org/0000-0003-4226-5704)
- Annelise A. Madison (ORCID: https://orcid.org/0000-0001-6091-6844)
- Richard T. Liu (ORCID: https://orcid.org/0000-0002-1367-9716)
- Andrew H. Miller (ORCID: https://orcid.org/0000-0001-8260-7997)
- Emma Lenoël Quang
Institutions
- Harvard University (US)
- Emory University (US)
- University of Michigan (US)
- Harvard University Press (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- American Journal of Psychiatry
- Published
- 2025-12-10
- DOI
- https://doi.org/10.1176/appi.ajp.20241115
- Citations
- 5
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.89