SRP/dGATAb modulates the ecdysone response bidirectionally via locus-specific regulatory landscape
Our data indicate that SRP/dGATAb positively regulates 20E-inducible transcription in S2 Schneider cells for some genes, functioning as a priming factor that facilitates EcR recruitment and chromatin acetylation. In contrast, for another subset of 20E-inducible genes, SRP/dGATAb exerts a negative regulatory effect, restraining activity of the regulatory sites.
Authors
- Darya Chetverina (ORCID: https://orcid.org/0000-0003-0008-3814)
- Maksim Erokhin (ORCID: https://orcid.org/0000-0002-2467-868X)
- Aleksandra A. Evdokimova
- Nadezhda E. Vorobyeva (ORCID: https://orcid.org/0000-0003-4293-834X)
- Anna Tarakanova (ORCID: https://orcid.org/0000-0002-6093-031X)
- Ming-an Sun (ORCID: https://orcid.org/0000-0002-4661-3027)
Institutions
- Institute of Gene Biology (RU)
- Yangzhou University (CN)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2025-12-10
- DOI
- https://doi.org/10.1186/s13072-025-00652-z
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00