Proteomics profiling of serum exosomes from azithromycin-sensitive and resistant Mycoplasma pneumoniae-infected patients reveals candidate biomarkers for diagnosis
The study successfully identified four potential biomarkers (KCTD12, LTF, TF, and MPO) for AZM resistance in <i>M. pneumoniae</i> infections. These biomarkers may serve as useful diagnostic tools in clinical settings, aiding in the identification of patients who may not respond to AZM treatment. Future research should focus on validating these biomarkers in larger cohorts and exploring their potential applications in clinical practice.
Authors
- Huifeng Fan (ORCID: https://orcid.org/0000-0002-1127-4256)
- Jing Zhou (ORCID: https://orcid.org/0000-0003-4468-8137)
- Diyuan Yang (ORCID: https://orcid.org/0000-0002-5353-1898)
- Gen Lu (ORCID: https://orcid.org/0009-0006-0161-5850)
- Feng Huang (ORCID: https://orcid.org/0000-0003-4203-4244)
- Qiang Ren (ORCID: https://orcid.org/0000-0002-2581-7709)
- Chen Chen (ORCID: https://orcid.org/0000-0002-5006-4278)
Institutions
- Liuzhou Maternal and Child Health Hospital (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-12-10
- DOI
- https://doi.org/10.3389/fmed.2025.1677573
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00