Tmem45b modulates itch via endoplasmic reticulum calcium regulation
Tmem45b plays a critical role in nonhistaminergic itch by regulating ER calcium homeostasis through Serca1. Its deficiency reduces itch behavior and impairs calcium signaling in DRG neurons, suggesting that Tmem45b is a potential therapeutic target for chronic itch.
Authors
- Zelin Sun (ORCID: https://orcid.org/0009-0000-2793-5373)
- Pengyu Y. Ren (ORCID: https://orcid.org/0000-0002-5613-1910)
- Liang Chen (ORCID: https://orcid.org/0000-0002-7507-3947)
- Sashuang Wang
- Wuping Sun (ORCID: https://orcid.org/0000-0003-2543-4369)
- Bin Wu (ORCID: https://orcid.org/0000-0002-9761-2139)
- Li Fu (ORCID: https://orcid.org/0000-0003-2643-6278)
- Changlin Li (ORCID: https://orcid.org/0000-0001-5872-6443)
- Ruolin Wang (ORCID: https://orcid.org/0000-0001-7249-6875)
- Lizu Xiao
- Juanjuan Sun (ORCID: https://orcid.org/0000-0002-2264-7732)
Institutions
- Northwestern Polytechnical University (CN)
- Shenzhen University (CN)
- Guangdong Polytechnic of Science and Technology (CN)
- Shenzhen Sixth People's Hospital (CN)
- Shenzhen University Health Science Center (CN)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-12-10
- DOI
- https://doi.org/10.3389/fphys.2025.1708686
- Citations
- 1
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.00