White matter hyperintensity modulates the amyloid‐tau‐cognition association and anti‐amyloid treatment efficacy in asymptomatic older adults
White matter hyperintensity (WMH) independently contributed to cognitive decline. WMH modulated the longitudinal relationship between Aβ and p-Tau217. WMH interacted with anti-amyloid treatment on longitudinal cognitive decline.
Authors
- Dengrong Jiang (ORCID: https://orcid.org/0000-0002-3843-1020)
- Qian Xiao (ORCID: https://orcid.org/0000-0001-8855-6561)
- Tengfei Guo (ORCID: https://orcid.org/0000-0003-2982-0865)
- Zixuan Lin (ORCID: https://orcid.org/0000-0001-9462-7768)
- Dan Wu (ORCID: https://orcid.org/0000-0002-9303-5821)
- Shin‐Lei Peng (ORCID: https://orcid.org/0000-0001-9241-1808)
- Yizhe Hu (ORCID: https://orcid.org/0009-0007-6114-4111)
- Yiwen Hong
Institutions
- Ministry of Education (NZ)
- Shanghai Jiao Tong University (CN)
- China Medical University (TW)
- Shenzhen Bay Laboratory (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.70990
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00