Obesity-induced gut microbiota transplantation promotes the occurrence and development of hepatocellular carcinoma
Our findings suggest that gut microbiota from obese donors directly promotes HCC progression via TLR4-NF-κB/mTOR-driven inflammation, fibrosis, and metabolic dysregulation, offering novel targets for microbiota-based interventions in obesity-associated liver cancer.
Authors
- Xiaoyan Ding (ORCID: https://orcid.org/0000-0001-5787-4401)
- Jian Wu (ORCID: https://orcid.org/0000-0003-0087-3744)
- Qiaoping Jin
- Mingxing Ding (ORCID: https://orcid.org/0000-0002-2006-703X)
- Wen Zheng
Institutions
- Women's and Children's Hospital (AU)
- Community Health Center (US)
- Jinhua University of Vocational Technology (CN)
- Ohara Memorial Institute for Science of Labour (JP)
Publication Details
- Journal
- Future Science OA
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1080/20565623.2025.2599729
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00