Development of language composites for enhanced sensitivity to multiple plasma biomarkers
Empirical language composite had optimal sensitivity to plasma p-tau217, NfL, GFAP. It comprises words/minute, filled pauses, proper name recall, and animal fluency. It offers potential for language-dominant ADRD precise detection and monitoring.
Authors
- Bruce P. Hermann (ORCID: https://orcid.org/0000-0003-0133-4427)
- Rachael Wilson
- Rebecca L. Koscik (ORCID: https://orcid.org/0000-0003-0025-744X)
- Deling He (ORCID: https://orcid.org/0000-0003-4690-6871)
- Kristin E Basche (ORCID: https://orcid.org/0000-0001-5767-8507)
- Erin M. Jonaitis (ORCID: https://orcid.org/0009-0004-5091-8255)
- Carol Van Hulle
- Kimberly D. Mueller (ORCID: https://orcid.org/0000-0001-8691-9517)
- Sterling C. Johnson
- Henrik Zetterberg
Institutions
- University of Wisconsin–Madison (US)
- Sahlgrenska University Hospital (SE)
- Institute for Neurodegenerative Disorders (US)
- University of Wisconsin Health (US)
- MRC Prion Unit (GB)
- Wisconsin Division of Public Health (US)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.70975
- Citations
- 1
- Primary Topic
- Biomedical Text Mining and Ontologies
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- European Commission
- Vetenskapsrådet
- National Institutes of Health
- HORIZON EUROPE Framework Programme