Degenerative pathologies on cortical biopsy, dopaminergic depletion, and shunt efficacy in iNPH
Cortical biopsy findings showed high concordance with amyloid PET in iNPH patients. AD pathology was linked to poorer cognitive and functional outcomes after surgery. VP shunting remained beneficial even in patients with comorbid AD pathology. Lower anterior striatal DAT uptake was paradoxically associated with better outcomes. Combined use of biopsy and DAT imaging may aid prognostication in iNPH management.
Authors
- So Hee Park (ORCID: https://orcid.org/0000-0003-0114-8587)
- Seun Jeon (ORCID: https://orcid.org/0000-0003-2817-3352)
- Sung Woo Kang (ORCID: https://orcid.org/0000-0001-9791-6899)
- Byoung Seok Ye (ORCID: https://orcid.org/0000-0003-0187-8440)
- Won Seok Chang (ORCID: https://orcid.org/0000-0003-3145-4016)
- Se Hoon Kim (ORCID: https://orcid.org/0000-0001-7516-7372)
Institutions
- Yonsei University (KR)
- Yeungnam University Medical Center (KR)
- Hanyang University (KR)
- Yeungnam University (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.70974
- Citations
- 1
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Yonsei University
- Korea Health Industry Development Institute
- Yonsei University College of Medicine