Imaging Metabotropic Glutamate Receptor 5 and Excitatory Neural Activity in Autism
This brain-wide investigation of mGlu5 availability with PET revealed pervasive lower mGlu5 availability across multiple brain areas in autism. Additionally, multimethod analyses revealed associations with a noninvasive electrophysiological index of excitatory neurotransmission. These results indicate that lower brain-wide mGlu5 availability may represent a molecular mechanism underlying altered excitatory neurotransmission that has the potential to stratify the heterogeneous autism phenotype.
Authors
- Nabeel Nabulsi (ORCID: https://orcid.org/0000-0001-8129-0051)
- Richard E. Carson (ORCID: https://orcid.org/0000-0002-9338-7966)
- Faranak Ebrahimian Sadabad (ORCID: https://orcid.org/0000-0002-6649-7211)
- Yanghong Yang (ORCID: https://orcid.org/0000-0002-6816-1252)
- Sheida Koohsari (ORCID: https://orcid.org/0000-0002-1997-9568)
- Lauren Pisani
- Caroline Finn (ORCID: https://orcid.org/0000-0003-4809-132X)
- Yiyun Huang (ORCID: https://orcid.org/0000-0001-5269-3775)
- Takuya Toyonaga (ORCID: https://orcid.org/0000-0002-0369-8294)
- Julie M. Wolf (ORCID: https://orcid.org/0000-0001-6677-7654)
- Ansel T. Hillmer (ORCID: https://orcid.org/0000-0002-8105-1381)
- James C. McPartland (ORCID: https://orcid.org/0000-0002-2570-0746)
- Jim Ropchan (ORCID: https://orcid.org/0000-0002-1105-7489)
- Brian Pittman (ORCID: https://orcid.org/0000-0002-0353-5604)
- Paul Gravel (ORCID: https://orcid.org/0000-0003-3702-7314)
- Irina Esterlis (ORCID: https://orcid.org/0000-0001-6293-1458)
- Nicole Herman (ORCID: https://orcid.org/0000-0001-8942-6857)
- Adam Naples (ORCID: https://orcid.org/0000-0002-6298-5699)
- David Matuskey (ORCID: https://orcid.org/0000-0001-7508-6572)
- Sophie Cramer-Benjamin (ORCID: https://orcid.org/0000-0001-5586-4111)
- Lindsey H. Rosenthal (ORCID: https://orcid.org/0000-0002-7154-5919)
- Cassandra J. Franke (ORCID: https://orcid.org/0000-0001-8969-1837)
- Bridget M. Walicki
- Jean-Dominique Gallezot
- Isabel G. Rodden
Institutions
- Yale University (US)
Publication Details
- Journal
- American Journal of Psychiatry
- Published
- 2025-12-10
- DOI
- https://doi.org/10.1176/appi.ajp.20241084
- Citations
- 3
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 4.29