Quantifying multimodal longitudinal brain changes in presymptomatic <i>C9orf72</i> disease
We studied longitudinal multimodal MRI changes in presymptomatic C9orf72 disease. Carriers displayed faster atrophy in putamen, insula and cerebellar regions. Mean diffusivity increased mainly in uncinate and thalamo-cortical tracts. These differences were even more significant in older (> 40) participants. We proposed targeted annualized rate of change as a quantitative biomarker.
Authors
- Olivier Colliot (ORCID: https://orcid.org/0000-0002-9836-654X)
- Raffaella Migliaccio (ORCID: https://orcid.org/0000-0002-6960-8474)
- Giorgia Querin (ORCID: https://orcid.org/0000-0001-6938-6368)
- Emilie Gérardin
- P. Couratier
- Armelle Rametti‐Lacroux (ORCID: https://orcid.org/0009-0006-2254-9370)
- Isabelle Le Ber (ORCID: https://orcid.org/0000-0002-2508-5181)
- Marion Houot
- Daisy Rinaldi
- Dario Saracino (ORCID: https://orcid.org/0000-0002-4299-9743)
- Lorenzo Cipriano (ORCID: https://orcid.org/0000-0002-5651-4970)
- Thibaud Lebouvier (ORCID: https://orcid.org/0000-0002-4386-6045)
- Pierre‐François Pradat (ORCID: https://orcid.org/0000-0003-1600-413X)
- David Wallon
- M.-P. Boncœur
Institutions
- Centre National de la Recherche Scientifique (FR)
- Institut national de recherche en sciences et technologies du numérique (FR)
- Inserm (FR)
- Université de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Sorbonne Université (FR)
- Laboratoire d’Imagerie Biomédicale (FR)
- Centre Hospitalier Universitaire de Limoges (FR)
- Pitié-Salpêtrière Hospital (FR)
- Institut d’Epidémiologie Neurologique et de Neurologie Tropicale (FR)
- Institut du Cerveau (FR)
- Centre Hospitalier Universitaire de Rouen (FR)
- Université de Rouen Normandie (FR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.70902
- Primary Topic
- Fetal and Pediatric Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- EU Joint Programme – Neurodegenerative Disease Research
- European Commission
- Agence Nationale de la Recherche
- Direction Générale de l’offre de Soins
- HORIZON EUROPE Framework Programme