Photoinduced Cobalt‐Catalyzed Reductive Coupling of Aryl Bromides and 1,4‐Dihydropyridines
The construction of C(sp<sup>2</sup>)─C(sp<sup>3</sup>) bond represents a fundamental yet challenging transformation in organic synthesis. Here, we reported a photoinduced cobalt-catalyzed reductive coupling reaction that efficiently constructs C(sp<sup>2</sup>)─C(sp<sup>3</sup>) bond between aryl bromides and 1,4-dihydropyridines. This protocol exhibits good functional group compatibility and broad substrate scope (31 examples, up to 93% yield) under mild reaction conditions. Mechanistic studies reveal that the alkylzinc reagents may be generated via photoinduced single-electron reduction, expanding the synthetic box for organozinc compound preparation.
Authors
- Ke Gao (ORCID: https://orcid.org/0000-0002-7011-1529)
- Ruirui Zhao (ORCID: https://orcid.org/0000-0002-6016-5275)
- Liang‐Qiu Lu (ORCID: https://orcid.org/0000-0003-2177-4729)
- Wei Xiong (ORCID: https://orcid.org/0000-0002-8826-2245)
- Wen‐Jing Xiao (ORCID: https://orcid.org/0000-0002-9318-6021)
- Zhen Su (ORCID: https://orcid.org/0000-0002-0402-2528)
- Qian Yang (ORCID: https://orcid.org/0000-0003-2987-6658)
Institutions
- Chinese Academy of Sciences (CN)
- Central China Normal University (CN)
- Lanzhou Institute of Chemical Physics (CN)
- Henan Normal University (CN)
- Wuhan Institute of Technology (CN)
Publication Details
- Journal
- Chemistry - An Asian Journal
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1002/asia.202500971
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00