Hypobaric hypoxia disrupts brown adipose thermogenic function in mice via Plin2 upregulation
We identify a novel hypoxia-lactate/PPARγ-Plin2 axis that uncouples body weight loss from BAT thermogenesis under hypobaric hypoxia. This pathway represents a previously unrecognized therapeutic target for counteracting metabolic dysfunction induced by high-altitude exposure.
Authors
- Yongfeng Hu (ORCID: https://orcid.org/0000-0002-7510-9444)
- Jialin Zhao (ORCID: https://orcid.org/0000-0002-1165-8911)
- Shaohang Xu (ORCID: https://orcid.org/0000-0002-6106-031X)
- Xinhua Liu (ORCID: https://orcid.org/0000-0002-9972-8215)
- Yuyu Zhang (ORCID: https://orcid.org/0000-0003-3095-3083)
- Jie Xu (ORCID: https://orcid.org/0000-0003-3848-092X)
- Jiayao Liu (ORCID: https://orcid.org/0000-0003-2160-0438)
- Jun Chang
Institutions
- Fudan University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Pudong Medical Center (CN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1111/dom.70371
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00