Adipose‐Derived Stem Cells Alleviate Denervation‐Induced Muscle Atrophy by Promoting <scp>M2</scp> Macrophage Polarization and Reducing Inflammation
ADSCs ameliorate denervation-induced muscle atrophy by improving muscle function and structure via M2 macrophage infiltration, MyoD upregulation, MMP2 inhibition, and reduced inflammation. These findings underscore the therapeutic potential of ADSCs for mitigating muscle atrophy following nerve injury, although the acute injury model used may not fully represent chronic clinical denervation.
Authors
- Qiannan Zhao (ORCID: https://orcid.org/0000-0001-8906-8113)
- Michiharu Sakamoto (ORCID: https://orcid.org/0000-0002-0024-6807)
- Takahiro Kuchimaru (ORCID: https://orcid.org/0000-0002-5355-3165)
- Tetsuji Yamaoka (ORCID: https://orcid.org/0000-0003-0225-2407)
- Yoshihiro Toyohara
- Naoki Morimoto (ORCID: https://orcid.org/0000-0002-8367-4777)
- Yuanjiaozi Li
- Yoshihiro Sowa (ORCID: https://orcid.org/0000-0002-7112-1630)
- Shino Higai
- Ogawa Koh
Institutions
- Jichi Medical University (JP)
- Kyoto University (JP)
- National Cerebral and Cardiovascular Center (JP)
- Jichi Medical University Hospital (JP)
Publication Details
- Journal
- Muscle & Nerve
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1002/mus.70094
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00