Longitudinal Dynamics of Plasma Neurofilament Light Chain in Hereditary Spastic Paraplegia Type 11 ( <scp>HSP</scp> ‐ <scp> <i>SPG11</i> </scp> ) and Type 15 ( <scp>HSP</scp> ‐ <scp> <i>ZFYVE26</i> </scp> )
Elevated pNfL reflects early neuroaxonal injury in HSP-SPG11 and HSP-ZFYVE26; however, it could not be used as a surrogate for disease progression. © 2025 International Parkinson and Movement Disorder Society.
Authors
- Kaitlyn Warren (ORCID: https://orcid.org/0000-0002-1273-3354)
- Kathryn Yang (ORCID: https://orcid.org/0009-0004-6892-5189)
- Jangsup Moon (ORCID: https://orcid.org/0000-0003-1282-4528)
- Hyo‐Min Kim (ORCID: https://orcid.org/0000-0002-2667-3719)
- Amy Tam (ORCID: https://orcid.org/0000-0003-2072-3436)
- Melissa Barghigiani (ORCID: https://orcid.org/0000-0001-5434-6806)
- Darius Ebrahimi‐Fakhari (ORCID: https://orcid.org/0000-0002-0026-4714)
- Julian E. Alecu (ORCID: https://orcid.org/0000-0002-1420-9775)
- Rebekah Mannix (ORCID: https://orcid.org/0000-0003-3608-2792)
- Grace Yoon (ORCID: https://orcid.org/0000-0002-3450-3293)
- Yoshihisa Takiyama (ORCID: https://orcid.org/0000-0002-5400-7107)
- Filippo Maria Santorelli (ORCID: https://orcid.org/0000-0002-1359-9062)
- Katerina Bernardi (ORCID: https://orcid.org/0009-0004-3387-7623)
- Luca Schierbaum (ORCID: https://orcid.org/0009-0002-4884-9647)
- Habibah A.P. Agianda (ORCID: https://orcid.org/0000-0002-5346-5026)
- Nicole Battaglia (ORCID: https://orcid.org/0009-0008-9751-4580)
- Joshua Rong (ORCID: https://orcid.org/0009-0001-5277-5794)
- Nunzio Setola
Institutions
- Boston Children's Hospital (US)
- Harvard University (US)
- Hospital for Sick Children (CA)
- Seoul National University Hospital (KR)
- Fondazione Stella Maris (IT)
- Yamanashi Prefectural Central Hospital (JP)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1002/mds.70142
- Primary Topic
- Hereditary Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00