Sleep fragmentation exacerbates myocardial ischemia-reperfusion injury via hypothalamic paraventricular nucleus-resident OX1R-mediated sympathetic hyperactivity in adult mice
SF may aggravate MI/RI through PVN OX1R-associated sympathetic hyperactivation. Pharmacological inhibition of OX1R improved cardiac outcomes, supporting the involvement of the PVN OX1R-sympathetic pathway in sleep disruption related cardiac injury.
Authors
- Caiyi Wang (ORCID: https://orcid.org/0000-0002-6317-3916)
- X Y Liu (ORCID: https://orcid.org/0000-0002-1259-9765)
- E Wang (ORCID: https://orcid.org/0000-0001-9463-9769)
- Lizhe Guo (ORCID: https://orcid.org/0000-0002-6131-7840)
- Na Chen (ORCID: https://orcid.org/0000-0001-8797-8535)
- Xiaocheng Zhu (ORCID: https://orcid.org/0000-0001-9600-0862)
- Xiang Chen (ORCID: https://orcid.org/0000-0003-2374-0020)
- Hao Hu
- Sisi Dai (ORCID: https://orcid.org/0000-0002-8262-8138)
- Yanan Cao (ORCID: https://orcid.org/0000-0003-0851-2927)
- Lu Wang (ORCID: https://orcid.org/0000-0003-2335-6088)
Institutions
- Central South University (CN)
- National Clinical Research (US)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1080/07853890.2025.2599059
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00