Combining IMPT and spot‐scanning hadron arc to efficiently boost dose and LET in hypoxic target volumes
We developed a new treatment strategy-LEOPARD, which can generate higher <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:semantics><mml:msub><mml:mi>LET</mml:mi> <mml:mi>d</mml:mi></mml:msub> <mml:annotation>${\rm LET}_{\mathrm{d}}$</mml:annotation></mml:semantics> </mml:math> in the HTV than IMPTBoost, while achieving better dose distribution and plan robustness compared to SHArcBoost. This work therefore indicates promising potential of LEOPARD for the treatment of hypoxic tumors.
Authors
- Emanuele Scifoni (ORCID: https://orcid.org/0000-0003-1851-5152)
- Guangru Li
- Lennart Volz (ORCID: https://orcid.org/0000-0003-0441-4350)
- Guoqing Xiao (ORCID: https://orcid.org/0000-0003-0703-4409)
- Christian Graeff (ORCID: https://orcid.org/0000-0002-5296-7649)
- Qiang Li (ORCID: https://orcid.org/0000-0003-0096-7679)
- Marco Durante (ORCID: https://orcid.org/0000-0002-4615-553X)
- Olga Sokol (ORCID: https://orcid.org/0000-0003-3664-7538)
Institutions
- Istituto Nazionale di Fisica Nucleare (IT)
- GSI Helmholtz Centre for Heavy Ion Research (DE)
- Chinese Academy of Sciences (CN)
- Technische Universität Darmstadt (DE)
- Istituto Nazionale di Fisica Nucleare, Trento Institute for Fundamental Physics And Applications (IT)
- Institute of Modern Physics (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Medical Physics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/mp.70176
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00