Distinctive tumor biology of oral squamous cell carcinoma associated with oral submucous fibrosis and its suppressive immune microenvironment
OSCC with OSF displays more aggressive tumor biological behavior and worse prognosis, which contributed by a more suppressive immune microenvironment marked by elevated levels of IL-17, Treg cells, and PD-1/PD-L1 expression. These results highlight the need for tailored treatment approaches in managing OSCC in patients with OSF.
Authors
- Baisheng Wang (ORCID: https://orcid.org/0000-0002-2019-7109)
- Cynthia Wang (ORCID: https://orcid.org/0000-0001-6414-3228)
- Mengbo Zhu (ORCID: https://orcid.org/0000-0002-5656-1427)
- Hongzhi Quan (ORCID: https://orcid.org/0000-0002-4408-9057)
- Xiaodan Fang (ORCID: https://orcid.org/0000-0001-8519-2109)
- Long Li (ORCID: https://orcid.org/0000-0003-4023-9238)
- Yan Wang (ORCID: https://orcid.org/0000-0003-2563-255X)
- Dezhi Wang (ORCID: https://orcid.org/0000-0003-2060-0532)
- Kun Li (ORCID: https://orcid.org/0000-0002-5924-4937)
- Yanjia Hu (ORCID: https://orcid.org/0000-0002-8221-4285)
- Senjeet Sreekissoon
- Tereda Seifu Neda
Institutions
- Central South University (CN)
- Hunan University (CN)
- Huzhou Normal University (CN)
- Third People's Hospital of Huzhou (CN)
- Second Xiangya Hospital of Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- BMC Oral Health
- Published
- 2025-12-10
- DOI
- https://doi.org/10.1186/s12903-025-07464-3
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00