Bidirectional Causal Effect Between Gut Microbiota and Glioma Risk: A Systematic Review‐Based Mendelian Randomization and Immune‐Mediated Effect Analysis
Our study, through MR analysis, revealed the causal relationship between gut microbiota and the susceptibility to glioma, and for the first time proposed the important role of circulating immune cells in this process, providing new potential biomarkers for the early diagnosis and treatment of glioma.
Authors
- Yuji Wang (ORCID: https://orcid.org/0000-0003-3842-7627)
- Yuxiang Fan (ORCID: https://orcid.org/0000-0001-9329-3866)
- Tianfu Han (ORCID: https://orcid.org/0000-0002-2362-2414)
- Mengqian Huang (ORCID: https://orcid.org/0000-0002-6009-0779)
- Chengzhuo Wang
- Yuxiao Chen (ORCID: https://orcid.org/0000-0003-3764-3504)
- Jiachen Wang (ORCID: https://orcid.org/0000-0001-5526-6816)
- Wenbin Li (ORCID: https://orcid.org/0000-0001-7638-4395)
- Rong Zhang (ORCID: https://orcid.org/0000-0001-5233-2718)
- Yilin Zhang (ORCID: https://orcid.org/0000-0001-5350-8279)
- Shenglan Li (ORCID: https://orcid.org/0009-0009-3685-0334)
- Zhuang Kang (ORCID: https://orcid.org/0009-0006-6962-0357)
- Xinrui Liu (ORCID: https://orcid.org/0000-0002-7754-5928)
Institutions
- Capital Medical University (CN)
- Beijing Tian Tan Hospital (CN)
Publication Details
- Journal
- Cancer Innovation
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/cai2.70039
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00