Characterizing CSF inflammatory proteomics in pediatric post-hemorrhagic hydrocephalus and Anti-NMDAR encephalitis
PHH and NMDARE revealed distinct neuroinflammatory proteomic signatures compared to our control samples. PHH was marked by a broad increase in detection of the majority of inflammation-related proteins, with highest representation among the alternative complement and coagulation-related pathways. The persistent detection of these proteins for weeks after the initial hemorrhage may be indicative of chronic neuroinflammation, even at the time of permanent CSF diversion. Conversely, NMDARE induced a narrower lymphocyte-driven profile, more consistent with an antibody-mediated autoimmune disease. Furthermore, suppression of NELL2 and up-regulation of immunoglobulin-related markers (IGLC2, MZB1, CD79B) are potential candidates for biomarkers in PHH and NMDARE, respectively.
Authors
- Nhu Chau
- Ankush Bansal (ORCID: https://orcid.org/0000-0002-5491-1243)
- Daniel A. Donoho (ORCID: https://orcid.org/0000-0002-0531-1436)
- Chima Oluigbo (ORCID: https://orcid.org/0000-0002-7851-3792)
- John S. Myseros
- Ilana Kahn (ORCID: https://orcid.org/0000-0002-0510-0276)
- Alexandra B. Kornbluh (ORCID: https://orcid.org/0000-0002-7880-918X)
- S. Leon Israel (ORCID: https://orcid.org/0000-0002-3227-0844)
- Helen Roper (ORCID: https://orcid.org/0000-0003-0870-3539)
- Akilah Pascall (ORCID: https://orcid.org/0000-0003-3545-729X)
- Leigh N. Sepeta (ORCID: https://orcid.org/0000-0003-4763-0045)
- Terry Dean (ORCID: https://orcid.org/0000-0002-8869-2464)
- Meghan Delaney (ORCID: https://orcid.org/0000-0003-1089-5787)
- William Suslovic
- Thomas Broudy (ORCID: https://orcid.org/0009-0003-5023-9765)
- Kazue Hashimoto‐Torii (ORCID: https://orcid.org/0000-0003-4001-8259)
- Claire Har (ORCID: https://orcid.org/0000-0001-5793-1015)
- Elizabeth Wells
- Robert Keating
- Hasan R. Syed
- Courtney Lowe (ORCID: https://orcid.org/0000-0001-5117-2118)
Institutions
- Children's National (US)
- George Washington University (US)
- Jefferson Hospital for Neuroscience (US)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-12-10
- DOI
- https://doi.org/10.1186/s12974-025-03642-w
- Citations
- 1
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39