ICG clearance as an indicator of augmented hepatic clearance and subtherapeutic drug concentrations in septic patients
AHC is a prevalent phenotype in sepsis and identifies a patient subgroup at high risk for subtherapeutic concentrations of hepatically or partially cleared antibiotics. ICG-derived parameters, particularly ICG-PDR, are robust predictors of inadequate drug exposure, supporting the use of dynamic liver function monitoring to optimize antibiotic dosing in septic patients.
Authors
- Danjiang Dong
- Xiaoting Wu (ORCID: https://orcid.org/0000-0001-8011-9324)
- Ying Xu (ORCID: https://orcid.org/0000-0003-2079-2394)
- Chen Qu (ORCID: https://orcid.org/0000-0002-0983-5720)
- Wenkui Yu (ORCID: https://orcid.org/0000-0003-1305-2005)
- Ming Yan (ORCID: https://orcid.org/0000-0002-6416-7489)
- Ning Liu (ORCID: https://orcid.org/0000-0001-5499-5849)
Institutions
- Nanjing Drum Tower Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
Publication Details
- Journal
- BMC Anesthesiology
- Published
- 2025-12-10
- DOI
- https://doi.org/10.1186/s12871-025-03534-9
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00