Social isolation, loneliness, and multi-system medical conditions: phenome-wide association and disease-trajectory analyses

These findings highlight the importance of integrating screening, interventions, and referrals for social isolation and loneliness into health care system to prevent the adverse health conditions.

Authors

Tao Sun (ORCID: https://orcid.org/0000-0001-7837-2101)
Xuemei Wang (ORCID: https://orcid.org/0000-0002-3516-0966)
Yaogang Wang (ORCID: https://orcid.org/0000-0003-2493-6471)
Zhi Cao (ORCID: https://orcid.org/0000-0003-1522-734X)
Chenjie Xu (ORCID: https://orcid.org/0000-0002-8997-9299)
Tingshan Duan

Institutions

Tianjin University of Traditional Chinese Medicine (CN)
Hangzhou Normal University (CN)
Peking University (CN)
Sir Run Run Shaw Hospital (CN)
First People's Hospital of Yuhang District (CN)
Tianjin Medical University (CN)
Zhejiang University (CN)

Publication Details

Journal: BMC Medicine
Published: 2025-12-10
DOI: https://doi.org/10.1186/s12916-025-04555-4
Primary Topic: Health disparities and outcomes
Type: article
Field-Weighted Citation Impact: 0.00

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article

Social isolation, loneliness, and multi-system medical conditions: phenome-wide association and disease-trajectory analyses

Tao Sun, Xuemei Wang, Yaogang Wang, Zhi Cao et al.

Dec 10, 2025

BMC Medicine

Health disparities and outcomes

article

Social isolation, loneliness, and multi-system medical conditions: phenome-wide association and disease-trajectory analyses

Tao Sun, Xuemei Wang, Yaogang Wang, Zhi Cao, Chenjie Xu, Tingshan Duan

December 10, 2025article en

Abstract

These findings highlight the importance of integrating screening, interventions, and referrals for social isolation and loneliness into health care system to prevent the adverse health conditions.

BMC MedicineVol. 24(1)

Tianjin University of Traditional Chinese Medicine (CN), Hangzhou Normal University (CN), Peking University (CN), Sir Run Run Shaw Hospital (CN), First People's Hospital of Yuhang District (CN), Tianjin Medical University (CN), Zhejiang University (CN)

Openalex Percentile: Top 52%

Health disparities and outcomes

DOI Open Access PDF OpenAlex

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Social isolation, loneliness, and multi-system medical conditions: phenome-wide association and disease-trajectory analyses — Tao Sun, Xuemei Wang, et al. · BMC Medicine (2025) | TGRS Research Map | TGRS