Hepatocyte and adipocyte CDO1-mediated intracellular cysteine catabolism differentially modulates diet-induced obesity and fatty liver in mice
Genetic manipulation of intracellular cysteine catabolism in hepatocytes and adipocytes differentially modulates diet-induced obesity and fatty liver, which warrants future mechanistic investigation to better understand cellular cysteine sensing mechanisms and cysteine control of cell metabolism.
Authors
- Tiangang Li (ORCID: https://orcid.org/0000-0001-8568-0129)
- David Matye (ORCID: https://orcid.org/0000-0001-6655-803X)
- Mohammad Nazmul Hasan (ORCID: https://orcid.org/0000-0003-4196-0406)
- Jianglei Chen (ORCID: https://orcid.org/0000-0001-8147-3894)
- Lijie Gu
- Yanhong Du
- Yung‐Dai Clayton
Institutions
- University of Oklahoma Health Sciences Center (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-09
- DOI
- https://doi.org/10.64898/2025.12.05.692669
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00