<i>IGF2BP3</i> binds to <i>FBXO32</i> to activate the cyclic guanosine monophosphate-protein kinase G pathway, promoting gastric cancer progression
<i>IGF2BP3</i> increases <i>FBXO32</i> protein expression in an m<sup>6</sup>A-dependent manner, activates the cGMP-PKG signaling pathway, and promotes GC progression. Targeting of the <i>IGF2BP3</i>/<i>FBXO32</i>/cGMP-PKG axis could thus represent a promising therapeutic modality for GC.
Authors
- Shuangshuang Han
- Hongyan Zhao (ORCID: https://orcid.org/0000-0002-5454-2759)
- Kunyi Liu (ORCID: https://orcid.org/0000-0001-7290-2941)
- Jia Wang (ORCID: https://orcid.org/0000-0002-3110-3892)
- Mingda Xuan
- Rui Zhang (ORCID: https://orcid.org/0000-0002-2878-3348)
- Hongfei Li (ORCID: https://orcid.org/0000-0001-5359-2853)
- Wenjing He (ORCID: https://orcid.org/0000-0002-9429-1894)
- Jiao Jiao (ORCID: https://orcid.org/0000-0002-5910-7238)
- Bo Tian (ORCID: https://orcid.org/0000-0002-8936-6783)
- Ting Liu (ORCID: https://orcid.org/0000-0002-8775-5507)
- Yi Si
- Yanhong Hu (ORCID: https://orcid.org/0000-0002-4635-6155)
- Weifang Yu
Institutions
- Hebei Medical University (CN)
- Hospital of Hebei Province (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- World Journal of Gastroenterology
- Published
- 2025-12-10
- DOI
- https://doi.org/10.3748/wjg.v31.i46.111631
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00