Behavioral and Prefrontal Circuit Deficits in a Newly Developed Setbp1 Haploinsufficiency Mouse Model
These data show that <i>Setbp1</i> <sup><i>+/-</i></sup> mice exhibit phenotypes parallel to the ADHD and ASD that are common in patients with <i>SETBP1</i>-HD. Additionally, we identified cellular changes to a key control center for attention, social behavior, and cognitive function that may elucidate the mechanism that underlies the neuropsychiatric disabilities of this disorder.
Authors
- Gregory J. Ordemann (ORCID: https://orcid.org/0000-0001-9755-7312)
- Polina N. Lyuboslavsky (ORCID: https://orcid.org/0000-0002-7689-8537)
- MacKenzie A. Howard (ORCID: https://orcid.org/0000-0003-2832-6873)
- Fernando Isaac Guillén (ORCID: https://orcid.org/0009-0002-3871-604X)
- Audrey C. Brumback (ORCID: https://orcid.org/0000-0002-4904-4368)
- Alena Kizimenko (ORCID: https://orcid.org/0000-0001-5192-0112)
- Mendee A. Geist
- Dominic M. Balice
- Emmanuella Bassey
Institutions
- The University of Texas at Austin (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-12-10
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100666
- Citations
- 1
- Primary Topic
- Attention Deficit Hyperactivity Disorder
- Type
- article
- Field-Weighted Citation Impact
- 1.47