Noninvasive detection and differentiation of gastric malignancy using cell-free DNA biomarkers
The cfDNA fragmentomics-based ensemble model enables accurate, non-invasive differentiation between gastric cancer and benign gastric lesions in high-risk or symptomatic patients. This approach demonstrates strong potential as a pre-endoscopy triage tool, supporting earlier detection and more efficient use of diagnostic resources.
Authors
- Haimeng Tang (ORCID: https://orcid.org/0000-0002-7519-8213)
- Xiuxiu Xu (ORCID: https://orcid.org/0000-0003-4199-7874)
- Chao Liu (ORCID: https://orcid.org/0000-0003-0316-4994)
- Dan Jiang (ORCID: https://orcid.org/0000-0002-8899-6425)
- Ruowei Yang (ORCID: https://orcid.org/0009-0007-1491-0207)
- Zhiwei Li (ORCID: https://orcid.org/0009-0008-3278-1047)
- Yushuai Song
- Hengzhen Li (ORCID: https://orcid.org/0000-0002-1140-3660)
- Henan Zhou
- Hua Bao (ORCID: https://orcid.org/0000-0001-5774-8755)
- Zhuo Chen (ORCID: https://orcid.org/0000-0001-6724-2571)
- Meng Chen (ORCID: https://orcid.org/0000-0001-7319-8570)
- Ying Liu (ORCID: https://orcid.org/0000-0002-4631-0915)
- Haitao Wang (ORCID: https://orcid.org/0000-0002-4570-8753)
- Wenhui Li (ORCID: https://orcid.org/0000-0002-2639-9975)
- Ling Qu
- Xiaona Fan
- Yisheng Dai
- Chaohua Mo (ORCID: https://orcid.org/0000-0003-2550-7900)
- Huike Yang (ORCID: https://orcid.org/0000-0003-3876-4914)
- Huaxing Wu
- Dongqin Zhu
- Guangtao Jiao
Institutions
- Harbin Medical University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Henan Cancer Hospital (CN)
- Genesee Community College (US)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jare.2025.12.005
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00