Adjuvant Epirubicin Plus Cyclophosphamide Followed by Taxanes With or Without Carboplatin in Early-Stage Triple-Negative Breast Cancer (RJBC 1501): A Randomized Phase III Trial
Adding carboplatin to adjuvant EC-T chemotherapy significantly improves DFS, DDFS, and OS in patients with early-stage TNBC. Although increased hematologic toxicity was observed, no new safety signals emerged.
Authors
- Xiaohong Xie (ORCID: https://orcid.org/0000-0001-7971-2112)
- Anqin Zhang (ORCID: https://orcid.org/0000-0003-1572-9585)
- Haoting Shi (ORCID: https://orcid.org/0000-0002-3744-5383)
- Fengzhe Zhang
- Yong Shi (ORCID: https://orcid.org/0000-0002-3074-6263)
- Mark D. Pegram (ORCID: https://orcid.org/0000-0002-9743-8118)
- Wei-Li Wu (ORCID: https://orcid.org/0000-0002-0934-9810)
- Xiaosong Chen (ORCID: https://orcid.org/0000-0002-0036-9444)
- Jundong Wu (ORCID: https://orcid.org/0000-0003-0607-8960)
- Shuwen Dong (ORCID: https://orcid.org/0000-0002-3374-5389)
- Xiangjing Chen
- Guolin Ye
- Weizhu Wu (ORCID: https://orcid.org/0000-0002-0988-4784)
- Weili Ren
- Jiahui Huang (ORCID: https://orcid.org/0000-0002-0389-1721)
- Yuechu Dai
- Kunwei Shen (ORCID: https://orcid.org/0000-0002-1961-8666)
- Yong Zeng (ORCID: https://orcid.org/0000-0001-6678-271X)
- Xiaodong Wang (ORCID: https://orcid.org/0000-0002-7233-4718)
- Zhian Li
- Qing Shao (ORCID: https://orcid.org/0000-0002-7850-8969)
- Qi He (ORCID: https://orcid.org/0000-0001-6000-2655)
- Juanying Zhu
- Yongan Chen (ORCID: https://orcid.org/0000-0003-1142-4119)
- Zhanwen Li
Institutions
- Fujian Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Wenzhou Medical University (CN)
- Ruijin Hospital (CN)
- Shantou University (CN)
- Cancer Hospital of Shantou University Medical College (CN)
- Jiaxing University (CN)
- Zhejiang Provincial Hospital of TCM (CN)
- Ruian People's Hospital (CN)
- Jiangyin People's Hospital (CN)
- First People's Hospital of Foshan (CN)
- International Peace Maternity & Child Health Hospital (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
- Shaoxing Second Hospital (CN)
- Ningde Normal University (CN)
- Zhejiang Hospital (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Lishui City People's Hospital (CN)
- Taizhou Central Hospital (CN)
- Guangdong Province Women and Children Hospital (CN)
- Wenzhou City People's Hospital (CN)
- Shaoxing People's Hospital (CN)
- Ningbo No.6 Hospital (CN)
- The Fifth People’s Hospital of Suzhou (CN)
- Stanford University (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-12-10
- DOI
- https://doi.org/10.1200/jco-25-02412
- Citations
- 1
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.94