Copper-Catalyzed Domino Reaction of Arylidene Isoxazolones with 2-(Pyridin-2-yl)acetate Derivatives under Ball Milling: A Rapid and Economical Synthesis of 3-Acylindolizines
A copper-catalyzed domino reaction of arylidene isoxazolones with 2-(pyridin-2-yl)acetate derivatives under ball-milling conditions has been developed. This protocol provides a rapid and economic approach to constructing a vast variety of biologically important 3-acylindolizines with remarkable functional group tolerance.
Authors
- Xingwang Hu (ORCID: https://orcid.org/0000-0002-2320-3279)
- Hui Xu (ORCID: https://orcid.org/0000-0003-3697-9612)
- Zeng‐Yang He
- Jiangtao Hu (ORCID: https://orcid.org/0000-0002-0210-9603)
- Luan-Ting Wu
- Ze Zhang (ORCID: https://orcid.org/0000-0001-9763-4592)
- Shuoyang Fan
Institutions
- China Tobacco (CN)
- Anhui Polytechnic University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1021/acs.orglett.5c04683
- Citations
- 2
- Primary Topic
- Synthesis and Reactivity of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 1.87