Regulatory T-cells in Reproductive Medicine: Implications for Endometriosis-Associated Infertility and Implantation Immunity

Regulatory T-cells (Tregs) are central to peripheral immune tolerance and act as key players that sustain the immune homeostasis required for embryo receptivity, implantation, and placentation. Treg dysfunction accelerates inflammation, angiogenesis, and lesion progression in endometriosis, whereas preclinical work indicates that adoptive Treg supplementation can restrain the advancement of endometriosis‑like lesions. Using the 2025 Nobel Prize in Physiology or Medicine scientific background as a starting point, this review summarizes Treg basic biology, roles in reproductive immunology, the pathophysiology of immune‑mediated infertility and endometriosis, and therapeutic prospects centered on Treg induction and supplementation.