Multidimensional cell-free DNA fragmentomics enables early detection of breast cancer
We have established a stacked ensemble model using cfDNA fragmentomics features and achieved superior sensitivity for detecting early-stage breast cancer, which could promote early diagnosis and benefit more patients.
Authors
- Meiqi Wang (ORCID: https://orcid.org/0000-0003-1333-650X)
- Zhenchuan Song (ORCID: https://orcid.org/0000-0003-3674-1946)
- Mengyang An
- Xinyue Hong (ORCID: https://orcid.org/0000-0003-4674-1819)
- Heageun Song
- Xinle Wang (ORCID: https://orcid.org/0000-0003-1177-1786)
- Xuan Zhang (ORCID: https://orcid.org/0000-0001-8775-1699)
- Lixian Yang
- Yang Liu (ORCID: https://orcid.org/0000-0003-0738-7415)
- Hua Yang (ORCID: https://orcid.org/0000-0001-7706-9020)
Institutions
- Hebei Medical University (CN)
- Hospital of Hebei Province (CN)
- Fourth Hospital of Hebei Medical University (CN)
- Xingtai People's Hospital (CN)
- Genesee Community College (US)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1186/s13058-025-02190-8
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00