Distinct mechanisms of cell in breast cancer and their clinical implication

Breast cancer is a heterogeneous disease affecting women globally. Despite significant advancements in therapeutic interventions in recent years, breast cancer remains a leading cause of cancer-related morbidity in women. Breast cancer's diverse molecular subtypes and escalating complexities in targeted therapies underscore the imperative need to explore novel therapeutic targets. The obstruction of apoptosis and the suppression of cell death are hallmarks of malignant tumors. Cell death, a pivotal regulatory event during tumorigenesis, includes apoptosis, anoikis, autophagy, necroptosis, ferroptosis, pyroptosis, and cuproptosis. This review systematically dissects the molecular underpinnings of cell death pathways in breast cancer, offering novel mechanistic insights and therapeutic opportunities to inform clinical management strategies.