Hypernatremia Enhances Transient Outward Potassium and Late Sodium Currents in a Mouse Model of Long QT Syndrome Type 3
Hypernatremia during Na<sub>v</sub>GOF prevents early ventricular repolarization due to I<sub>to</sub> activation (mouse) and prolongs repolarization in the absence of I<sub>to</sub> (guinea pig). Future studies in animal models electrophysiologically similar to humans are needed to determine if hypernatremia and perinexal expansion are proarrhythmic during Na<sub>v</sub>GOF.
Authors
- Robert G. Gourdie (ORCID: https://orcid.org/0000-0001-6021-0796)
- Steven Poelzing (ORCID: https://orcid.org/0000-0002-6979-1264)
- Xiaobo Wu (ORCID: https://orcid.org/0000-0002-3136-5059)
- Peter Carmeliet (ORCID: https://orcid.org/0000-0001-7961-1821)
- Sharon A. Swanger (ORCID: https://orcid.org/0000-0003-0615-6244)
- Gregory S. Hoeker (ORCID: https://orcid.org/0000-0002-3917-4791)
- Seth H. Weinberg (ORCID: https://orcid.org/0000-0003-1170-0419)
- Rowan O. Maisonneuve
Institutions
- Khalifa University of Science and Technology (AE)
- Carilion Roanoke Memorial Hospital (US)
- Virginia–Maryland College of Veterinary Medicine (US)
- VIB-KU Leuven Center for Cancer Biology (BE)
- Lung Institute (US)
- Biomedical Research Institute (US)
- Carilion Clinic (US)
- Virginia Tech (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-09
- DOI
- https://doi.org/10.64898/2025.12.04.692461
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00