Therapeutic Targeting of Epithelial–Mesenchymal Cellular Plasticity in Pancreatic Cancer

GSK-3β blockade synergizes with FFX by modulating PDAC plasticity while promoting the development of a tumor-suppressive immune microenvironment.

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Publication Details

Journal
Clinical Cancer Research
Published
2025-12-09
DOI
https://doi.org/10.1158/1078-0432.ccr-25-2052
Primary Topic
Immune cells in cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

Therapeutic Targeting of Epithelial–Mesenchymal Cellular Plasticity in Pancreatic Cancer

Jung Woo Bae, Mukesh G. Harisinghani, G. Newbert, Mingjuan Lisa Zhang et al.
Clinical Cancer Research
Immune cells in cancer
article

Therapeutic Targeting of Epithelial–Mesenchymal Cellular Plasticity in Pancreatic Cancer

Jung Woo Bae, Mukesh G. Harisinghani, G. Newbert, Mingjuan Lisa Zhang, Raul N. Uppot, David Tsai Ting, Michael J. Raabe, Aileen O’Shea, Nicole A. Lester, Katherine H. Xu, Joshua R. Kocher, Colin D. Weekes, Aparna R. Parikh, Jonah Cohen, Linda T. Nieman, William L. Hwang, Bidish K. Patel, Brian C. Jacobson, Andrea Hansen, Brenna Casey, Ralph Weissleder, Nora Horick, Ildiko E. Phillips, Lawrence Scott Blaszkowsky, Akwi W. Asombang, Eric W. Lin, Preeti Pathak, Elizabeth Walsh, Kumar Krishnan, Beatrice W. Awasthi, Joanna Caufield
article en

Abstract

GSK-3β blockade synergizes with FFX by modulating PDAC plasticity while promoting the development of a tumor-suppressive immune microenvironment.

Clinical Cancer ResearchVol. 32(5)
Boston University (US), Beaumont Hospital (IE), Harvard University Press (US), University of Massachusetts Boston (US), Massachusetts General Hospital (US), Center for Cancer Research (US), Center for Systems Biology (US), Mass General Brigham (US)
Openalex Percentile: Top 55%
Immune cells in cancer
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