Therapeutic Targeting of Epithelial–Mesenchymal Cellular Plasticity in Pancreatic Cancer
GSK-3β blockade synergizes with FFX by modulating PDAC plasticity while promoting the development of a tumor-suppressive immune microenvironment.
Authors
- Jung Woo Bae (ORCID: https://orcid.org/0000-0001-5745-4896)
- Mukesh G. Harisinghani (ORCID: https://orcid.org/0000-0003-0993-1947)
- G. Newbert (ORCID: https://orcid.org/0009-0008-1379-6446)
- Mingjuan Lisa Zhang (ORCID: https://orcid.org/0000-0002-8029-4787)
- Raul N. Uppot (ORCID: https://orcid.org/0000-0001-6165-4911)
- David Tsai Ting (ORCID: https://orcid.org/0000-0002-3261-2322)
- Michael J. Raabe (ORCID: https://orcid.org/0009-0009-7345-7507)
- Aileen O’Shea (ORCID: https://orcid.org/0000-0002-2172-7087)
- Nicole A. Lester (ORCID: https://orcid.org/0009-0006-4506-0260)
- Katherine H. Xu (ORCID: https://orcid.org/0009-0002-8688-5702)
- Joshua R. Kocher (ORCID: https://orcid.org/0009-0006-4418-9898)
- Colin D. Weekes (ORCID: https://orcid.org/0000-0001-6287-4334)
- Aparna R. Parikh (ORCID: https://orcid.org/0000-0002-5245-7841)
- Jonah Cohen (ORCID: https://orcid.org/0000-0001-9630-0531)
- Linda T. Nieman (ORCID: https://orcid.org/0000-0002-0141-8308)
- William L. Hwang (ORCID: https://orcid.org/0000-0003-4514-8837)
- Bidish K. Patel (ORCID: https://orcid.org/0000-0002-5931-1917)
- Brian C. Jacobson (ORCID: https://orcid.org/0000-0001-7064-2357)
- Andrea Hansen (ORCID: https://orcid.org/0000-0003-4426-4035)
- Brenna Casey (ORCID: https://orcid.org/0000-0001-6426-0838)
- Ralph Weissleder (ORCID: https://orcid.org/0000-0003-0828-4143)
- Nora Horick (ORCID: https://orcid.org/0000-0002-4355-5853)
- Ildiko E. Phillips (ORCID: https://orcid.org/0000-0002-5752-998X)
- Lawrence Scott Blaszkowsky (ORCID: https://orcid.org/0000-0002-9437-2977)
- Akwi W. Asombang (ORCID: https://orcid.org/0000-0002-8658-6772)
- Eric W. Lin (ORCID: https://orcid.org/0000-0002-1064-2010)
- Preeti Pathak (ORCID: https://orcid.org/0009-0008-9269-3583)
- Elizabeth Walsh (ORCID: https://orcid.org/0009-0002-3540-7217)
- Kumar Krishnan (ORCID: https://orcid.org/0009-0001-3872-3699)
- Beatrice W. Awasthi (ORCID: https://orcid.org/0000-0002-2686-8997)
- Joanna Caufield (ORCID: https://orcid.org/0009-0003-7116-4782)
Institutions
- Boston University (US)
- Beaumont Hospital (IE)
- Harvard University Press (US)
- University of Massachusetts Boston (US)
- Massachusetts General Hospital (US)
- Center for Cancer Research (US)
- Center for Systems Biology (US)
- Mass General Brigham (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-2052
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00