S1653 Cardiovascular Risk Factors Drive Mortality in Patients With Inflammatory Bowel Disease—A Propensity-Matched US National Database Study

Introduction: Inflammatory bowel disease (IBD) is associated with an increased risk of adverse cardiovascular (CV) events and venous thromboembolism (VTE), though its impact on mortality remains debatable. The ORAL Surveillance study found that tofacitinib, a Janus kinase inhibitor approved for ulcerative colitis (UC), was linked to increased mortality in rheumatoid arthritis patients, particularly those with CV risk factors (RFs). We aimed to determine all-cause mortality in IBD patients and assess the role of CV and VTE RFs. Methods: We performed a retrospective cohort study using multi-institutional database TriNetX. IBD patients [UC and Crohn’s Disease (CD)] were identified between 2015 to 2023 with the presence of LOINC codes for IBD medications (to increase the validity of diagnosis codes). Data was collected for demographics, IBD medications, CV RFs, VTE RFs and history of coronary artery disease (CAD). We compared IBD patients to 1:1 propensity score matched non IBD controls for age, gender, race, and ethnicity for outcome of all-cause mortality [specific CV mortality data is not validated in TriNetx]. Patients with other chronic inflammatory disorders, celiac disease, and malignancy were excluded. All outcomes were assessed after the IBD index date. Odds Ratios (OR) was used to assess association between IBD and mortality. Logistic regression was used to evaluate the impact of individual RFs in the IBD cohort. Results: We identified 110,116 IBD patients (49% UC, 51% CD) and propensity matched non-IBD controls. Even though, IBD patients had a higher prevalence of CV RFs, VTE RFs, and CAD IBD was associated with overall lower all-cause mortality compared to controls (OR 0.89, 95% CI 0.85–0.91, P < 0.001). On further analysis of the IBD cohort with logistic regression, IBD patients with CV RFs, especially CAD had increased mortality as compared to IBD patients without CV RFs (IBD only OR 0.88, 95% CI 0.84–0.91 vs IBD + CAD OR 4.41, 95% CI 4.18–4.65). Prior VTE was not associated with increased mortality. Conclusion: IBD patients have lower all-cause mortality compared to matched non-IBD controls. However, the presence of CV RFs—particularly CAD—significantly increases mortality risk. Identifying and managing CV comorbidities in IBD patients is essential to improving long-term outcomes.